Inhibition of platelet glycoprotein Ib and its antithrombotic potential.
作者： Karen Vanhoorelbeke , Hans Ulrichts , Gerlinde de Walle , Alexandre Fontayne , Hans Deckmyn
DOI: 10.2174/138161207781662867
关键词:
摘要: The platelet receptor glycoprotein (GP)Ib-IX-V complex plays a dominant role in the first steps of adhesion and arterial thrombus formation. Through its interaction with multimeric plasma protein von Willebrand factor (VWF), which is bound to damaged subendothelial structures, GPIb-IX-V tethers platelets from flowing blood thereby slowing them down. This step prerequisite for collagen receptors participate firm resulting formation layer basis further Recently, other ligands besides extensively studied VWF have been identified, such as : α-thrombin, coagulation XII (FXII), high molecular weight kininogen (HMWK), XI (FXI), integrin Mac-1 P-selectin. In this review, different described anticipated or demonstrated vivo effects are discussed.
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