The role of alternative testing strategies in environmental risk assessment of engineered nanomaterials

摘要: Within toxicology there is a pressure to find new test systems and organisms replace, reduce refine animal testing. In nanoecotoxicology the need for alternative testing strategies (ATS) further emphasized as validity of tests risk assessment practices developed dissolved chemicals are challenged. Nonetheless, standardized whole organism still considered gold standard environmental assessment. Advancing analysis engineered nanomaterials (ENMs) through ATS was discussed in September 2014 at an international Society Risk Analysis (SRA) workshop Washington, D.C. serves point departure this paper. Here we present main outcomes by describing defining use ENMs well discussing its future role science. We conclude that diversity should be encouraged avoid “selective ignorance” that, iterative process with low-tier high-tier testing, data-generation can validated ensure relevant endpoints. Furthermore, simplified screening could enable early decision-making on material design, while complex multispecies studies utilized skip uncertain extrapolations give rise more accurate analysis.