The Role of Oxidative Stress in Diabetes Mellitus: A 24-year Review

作者: CF Ubajaka , UE Ebenebe , AL Ilika , CC Ilechukwu , OF Emelumadu

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摘要: Background: Diabetes mellitus is a widespread and devastating disease. associated with several mechanisms of tissue damage, one which oxidative stress. Oxidative stress damage to tissues are common end points chronic diseases such as atherosclerosis, diabetes cardiovascular diseases. plays an important role in the pathogenesis complications diabetes. Hyperglycaemia results overproduction oxygen free radicals contributes progression Objective: This review aims at determining diabetic complications. Method: Relevant literatures were reviewed from medical journals, library search, Pub Med Google search other internet engines (Google Scholar, Hinarii, Ask.com) 1987 2011. Results: Several studies demonstrated that also development Conclusion : Increasing evidence has implicated for Antioxidant therapy been effective management In addition, physical exercise insulin can improve through reduction Keywords stress, radicals, antioxidants, diabetes,

参考文章(27)
Sen Ck, Oxygen toxicity and antioxidants: state of the art. Indian journal of physiology and pharmacology. ,vol. 39, pp. 177- 196 ,(1995)
Barry Halliwell, How to characterize an antioxidant: an update Biochemical Society Symposia. ,vol. 61, pp. 73- 101 ,(1995) , 10.1042/BSS0610073
Paul Curnow, David Stephens, PJ Booth, M Lorch, Harry Mellor, Biochemical Society Symposium ,(2005)
Hiroaki Miyajima, Yoshitomo Takahashi, Satoshi Kono, Aceruloplasminemia, an inherited disorder of iron metabolism. Biometals. ,vol. 16, pp. 205- 213 ,(2003) , 10.1023/A:1020775101654
Stellan Sandler, Annika K. Andersson, Andreea Barbu, Claes Hellerström, Maria Holstad, Ella Karlsson, Jan-Olov Sandberg, Eva Strandell, Johan Saldeen, Johnny Sternesjö, Linda Tillmar, Decio L. Eizirik, Malin Flodström, Nils Welsh, Novel Experimental Strategies to Prevent the Development of Type 1 Diabetes Mellitus Upsala Journal of Medical Sciences. ,vol. 105, pp. 17- 34 ,(2000) , 10.1517/03009734000000053
Dr. C.K. Lauritzen, Federation of European biochemical Societies FEBS Letters. ,vol. 524, pp. 230- 231 ,(2002) , 10.1016/S0014-5793(02)03019-3
HONG KYU LEE, KYONG SOO PARK, YOUNG MIN CHO, YUN YONG LEE, YOUNGMI KIM PAK, Mitochondria‐Based Model for Fetal Origin of Adult Disease and Insulin Resistance Annals of the New York Academy of Sciences. ,vol. 1042, pp. 1- 18 ,(2005) , 10.1196/ANNALS.1338.001
Dean P. Jones, Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Research. ,vol. 9, pp. 169- 181 ,(2006) , 10.1089/REJ.2006.9.169
L. B. Borghouts, H. A. Keizer, Exercise and insulin sensitivity: a review. International Journal of Sports Medicine. ,vol. 21, pp. 1- 12 ,(2000) , 10.1055/S-2000-8847