A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn

摘要: Background Neonatal alloimmune thrombocytopenia is most commonly due to transplacental passage of maternal anti-HPA 1a antibodies. A prospective study was carried out evaluate the pattern and quantity antibodies in order predict level neonates. Design Methods monoclonal antibody immobilization platelet antigen assay used detect samples from 1,990 HPA 1bb women. HLA DRB3*0101 typing performed all immunized women by sequencing DRB3 gene when present. Results Primary immunization more often took place connection with delivery than during first pregnancy. There a strong correlation between levels counts newborn (R2=0.49, p <0.001). above 3.0 IU/mL measured gestational week 22 or 34 had diagnostic sensitivity specificity 93% 63%, respectively, for predicting grade neonatal thrombocytopenia. The who were negative significantly lower those positive ( <0.007). In contrast primigravida, whom increased pregnancy, decreased 92 147 been pregnant previously (P92 = 0.003). regularly after delivery. Conclusions Maternal weeks pregnancy are good predictors degree both subsequent pregnancies. Most mothers became at time delivery.