Identifying risk factors involved in the common versus specific liabilities to substance use: A genetically informed approach

摘要: Individuals most often use several rather than one substance among alcohol, cigarettes or cannabis. This widespread co-occurring of multiple substances is thought to stem from a common liability that partly genetic in origin. Genetic risk may indirectly contribute through genetically influenced mental health vulnerabilities and individual traits. To test this possibility, we used polygenic scores indexing traits examined their association with the versus specific liabilities use. We data Avon Longitudinal Study Parents Children (N = 4218) applied trait-state-occasion models delineate substance-specific factors based on four classes (alcohol, cigarettes, cannabis other illicit substances) assessed over time (ages 17, 20 22). generated 18 In multivariable regression, then tested independent contribution selected factors. Our results implicated use, notably taking (bstandardised 0.14; 95% confidence interval [CI] [0.10, 0.17]), followed by extraversion -0.10; CI [-0.13, -0.06]), schizophrenia 0.06; [0.02, 0.09]). Educational attainment (EA) body mass index (BMI) had opposite effects such as cigarette (bstandardised-EA -0.15; [-0.19, -0.12]; bstandardised-BMI 0.05; 0.09]) alcohol 0.07; [0.03, 0.11]; -0.06; [-0.10, -0.02]). These findings point towards largely distinct sets influences liabilities.