Treatment of Paget's disease with the calcitonins.
作者： T. J. Martin
DOI: 10.1111/J.1445-5994.1979.TB04110.X
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摘要: Summary: Calcitonin has been used in the treatment of Paget's Disease bone because its ability to inhibit osteoclastic resorption. This results a return turnover towards normal, as reflected by urinary hydroxyproline and serum alkaline phosphatase. A plateau is reached with these parameters, at about 50% pre-treatment level. The cause this unknown, but does not indicate resistance treatment, since it occurs all forms calcitonin. Most treated patients experience pain relief, there radiological histological evidence arrested progression Both primary secondary calcitonin occur calcitonins, including homologous hormone. Antibodies develop commonly pig or salmon calcitonin, antibody-based clinical demonstrated only few patients. Methods selection for assessment response are discussed, schedules summarized.
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