Repeated Exposure to Severely Limited Sleep Results in Distinctive and Persistent Physiological Imbalances in Rats

摘要: Chronic sleep disruption in laboratory rats leads to increased energy expenditure, connective tissue abnormalities, and weights of major organs relative body weight. Here we report on expanded findings the extent which abnormalities become long-lasting, potentially permanent changes health status after apparent recuperation from chronic disruption. Rats were exposed 6 times long periods disrupted or control conditions during 10 weeks produce adaptations then permitted nearly 4 months undisturbed sleep. Measurements made tissues these groups preserved experimental an antecedent study that lacked a lengthy period. Cycles restriction resulted deficiency marked by progressive course hyperphagia (15%) weight loss. Analyses composition chronically sleep-restricted indicated protein lipid amounts internal largely spared, while adipose depots appeared depleted. This suggests high metabolic demands may have size vital expectations severe alone. Low plasma corticosterone leptin concentrations appear reflect low substrate availability diminished adiposity. After recuperation, consuming 20% more food 35% water than did comparison rats, despite normalized weight, adipocytes, elevated concentrations. Plasma cholesterol levels recuperated those controls. The intake nutriments water, along with altered negative feedback regulation use, indicate processes are modified period prolonged insufficient has ended.