Plantago major protective effects on antioxidant status after administration of 7,12-Dimethylbenz(a)anthracene in rats.
作者： Halit Demir , Hulya Ozdemir , Abdulkadir Levent , Gokhan Oto , Suat Ekin
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摘要: Aim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and 3 receiving the aqueous at 100 mg/kg/d for 60 days. Results: Significant decrease catalase (P<0.05), carbonic anhydrase (p≤0.01), reduced glutathione (GSH) (P<0.01) total protein values observed compared healthy controls + groups. Conclusion: results suggest preventive induced damage that might be due decreased free radical generation.
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