The EGF receptor - an essential regulator of multiple epidermal functions.

摘要: Epidermal keratinocytes express both the epidermal growth factor receptor (EGFR) and several of its ligands, establishing constitutive elements an autocrine loop in this cell type. Activation EGFR provides signals essential to aspects normal keratinocyte biology including cycle progression, differentiation, movement cellular survival. It may be argued that enhanced survival via activation is most important function as it limits manifestation other phenotypes. The frequent deregulation expression benign malignant hyperproliferative skin diseases motivates investigation EGFR-dependent intracellular pathways which contribute varied