Mortality, Asthma, Smoking and Acute Chest Syndrome in Young Adults with Sickle Cell Disease

摘要: Sickle cell disease (SCD) patients with asthma have an increased risk of death. Acute chest syndrome (ACS) is a major cause mortality in SCD, and ACS may be more common SCD who smoke. The purpose this study was to test the hypothesis that young adults would greater than controls during 10-year period determine whether asthma, reduced lung function, episodes, and/or smoking predicted follow-up period. outcomes were ascertained race-matched had taken part pulmonary function when they between age 19 27 years. Smoking status episodes determined, measured at initial assessment. Seventy-five subjects followed for 683 patient years. There 11 deaths rate 1.6 per 100 years, which higher controls; one death 47 observed 469 years 0.2 (p = 0.03). no significant associations body mass index, recurrent acute chest, steady state haemoglobin, or gender mortality. Adjusting baseline patients, “current” [hazard ratio (HR) 11.2; 95 % confidence interval (CI) 2.5–50.6; p = 0.002] [HR 2.7; (95 % CI 1.3–5.5); p = 0.006] significantly associated Our results indicate should discouraged from their aggressively treated.