Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets
作者： Yonghae Son , Min Kyung Jang , Myeong Ho Jung
关键词:
摘要: Vigna species are important food resources and traditionally used for the treatment of various diseases. In this study, we examined inhibitory effects nakashimae (VN) extract on high-fat diet (HFD)-induced hepatic steatosis elucidated molecular mechanisms. C57BL/6J mice were fed an HFD with or without VN 16 weeks. decreased HFD-induced body weight, liver lipid accumulation, plasma alanine aminotransferase, suppressed oxidative stress inflammation associated hepatitis. levels expression lipogenic genes in livers HFD-fed mice. significantly increased phosphorylation adenosine monophosphate (AMP)-activated protein kinase (AMPK) acetyl-CoA carboxylase, fatty acid oxidation VN-treated HepG2 cells. Further, inhibited insulin glucose-stimulated lipogenesis conclusion, prevents lipotoxicity through AMPK activation.
sci-hub.se 参考文章(28)
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
Yonghae SON, Jeong-Su NAM, Min-Kyung JANG, In-Ah JUNG, Su-In CHO, Myeong-Ho JUNG, Antiobesity Activity of Vigna nakashimae Extract in High-Fat Diet-Induced Obesity Bioscience, Biotechnology, and Biochemistry. ,vol. 77, pp. 332- 338 ,(2013) , 10.1271/BBB.120755
Zecharia Madar, Aliza H. Stark, New legume sources as therapeutic agents. British Journal of Nutrition. ,vol. 88, pp. 287- 292 ,(2002) , 10.1079/BJN2002719
Bei B. Zhang, Gaochao Zhou, Cai Li, AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome Cell Metabolism. ,vol. 9, pp. 407- 416 ,(2009) , 10.1016/J.CMET.2009.03.012
Seong Hwan Hwahng, Sung Hwan Ki, Eun Ju Bae, Hyun Eun Kim, Sang Geon Kim, Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology. ,vol. 49, pp. 1913- 1925 ,(2009) , 10.1002/HEP.22887
Yanping Zou, Yanhua Lu, Dongzhi Wei, Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. Journal of Agricultural and Food Chemistry. ,vol. 52, pp. 5032- 5039 ,(2004) , 10.1021/JF049571R
Y. Mukai, S. Sato, Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutrition Metabolism and Cardiovascular Diseases. ,vol. 19, pp. 491- 497 ,(2009) , 10.1016/J.NUMECD.2008.09.007
Takehisa Isemura, Akito Kaga, Saeko Konishi, Tsuyu Ando, Norihiko Tomooka, Ouk Kyu Han, Duncan A. Vaughan, Genome Dissection of Traits Related to Domestication in Azuki Bean (Vigna angularis) and Comparison with other Warm-season Legumes Annals of Botany. ,vol. 100, pp. 1053- 1071 ,(2007) , 10.1093/AOB/MCM155
D. Grahame Hardie, Fiona A. Ross, Simon A. Hawley, AMPK: a nutrient and energy sensor that maintains energy homeostasis Nature Reviews Molecular Cell Biology. ,vol. 13, pp. 251- 262 ,(2012) , 10.1038/NRM3311
Joyce J Repa, Guosheng Liang, Jiafu Ou, Yuriy Bashmakov, Jean-Marc A Lobaccaro, Iichiro Shimomura, Bei Shan, Michael S Brown, Joseph L Goldstein, David J Mangelsdorf, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Genes & Development. ,vol. 14, pp. 2819- 2830 ,(2000) , 10.1101/GAD.844900