Cytotoxicity of extracellular Legionella pneumophila

摘要: Legionella pneumophila, the causative agent of Legionnaire's disease and Pontiac fever, is known to produce a cytopathic effect on macrophages. The capacity extracellular L. pneumophila mediate toxicity for guinea pig peritoneal macrophages J774 mouse was assessed. Extracellular organisms were found be capable mediating toxicity; however, toxic activity appeared require close proximity with mononuclear cell surface. Serogroup 1 strains grown supplemented Mueller-Hinton agar exhibited variable expression activity. One strain positive cytotoxic unable replicate in but remained virulent pigs at high doses.