A Longitudinal Evaluation of the Relationship Between First Morning Urinary

摘要: Cortisol is one of the most frequently used stress biomarkers in humans. Urine and saliva are matrices choice to longitudinally monitor cortisol levels. Salivary urinary often discussed as though they provide similar information. However, relationship between "free" levels urine (nonconjugated) (non-protein-bound) has yet be properly evaluated using naturalistic designs. Objectives: To investigate longitudinal salivary (SC) first morning (FMUC), compare advantages disadvantages these assessing changes secretion Methods: from 31 healthy, Kakchiquel Mayan women Guatemala were compared morn- ing (FMU) four specimens collected daily across three alternate days. Linear mixed-effect regression models including fixed random effects analyze repeated-measures data. Results: FMUC (16.04-242.18 ng/ml) higher than SC (0.21-5.16 ng/ml). A small but statistically significant was found (each 1 ng/ml increase predicted a 0.1% SC; P < 0.05). Conclusions: Nonconjugated related non-protein-bound throughout day. FMU presents several over for assessment studies. about 53-fold saliva, which makes between- within-individual variation easier detect, less likely affected by confounders diurnal Am. J. Hum. Biol. 00:000- 000, 2013. V C 2013 Wiley Periodicals, Inc.