Customized antigens for desensitizing allergic patients.

摘要: Publisher Summary The most effective allergy treatment is one that specifically and with maximum safety cures clinical symptoms caused by allergens in any given patient. In this chapter, allergen-specific immunotherapy (SIT) offers the best possibility of accomplishing goal. process highly specific because targeted at those patient physician identified as responsible ones. For performance tailor-made type treatment, first crucial step exact identification molecules causing allergic reaction—that is, a clear diagnosis establishing association between disease manifestation immunoglobulin (IgE)-mediated immune reactions. This accomplished molecule-based diagnosis. Genetic immunization an attractive alternative for SIT using protein antigens. Intramuscular or intradermal injection plasmid DNA encoding clinically relevant can induce long-lasting responses Th1 bias promote formation interferon-γ–producing CD4 + T cells. Molecular cloning recombinant production opened new possibilities increasing problem allergies. concept molecule based implemented field. Molecule-based allows not only precise allergen recognition patterns individual patients quantification IgE levels to each allergen, but also helps predict potential sensitization multiple allergenic sources resulting from cross-reactivity phenomenon.