Stimulation of LH fragments with reduced bioactivity following GnRH agonist administration in women.

摘要: In eumenorrheic women with endometriosis and in oligo-amenorrheic polycystic ovarian disease (PCO), chronic administration of a long-acting GnRH agonist (GnRH-a) reduced the circulating concentrations estrogens androgens to levels similar those castrated women. The concommittant elevation LH both groups suggested that measured immunoreactive had reducedbioactivity. seven endometriosis, bioactive (BA LH) as in-vitro secretion testosterone by dispersed Leydig cells, was significantly (p < 0.001)reduced from 10.8 ± 1.2 (SEM) 4.4 0.2 mlU/ml at end 28 days GnRH-a therapy. five PCO, BA decreased 44.2 15.5 5.7 0.6 mlU/ml(p = 0.06). These changes appeared be responsible for suppression androgen during treatment turn may have contributed profound decreases estrogen production reducing amount precursor available aromatiz...