Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins.

摘要: Recently, there has been growing attention to the role of tumor microenvironment (TME) in cancer growth, metastasis and emergence chemotherapy resistance. Stromal cells make up TME interact with each other through a complex cross-talk manner. This interaction is facilitated by variety growth factors, cytokines, chemokines S100 proteins. In this review, we focus on their cognate receptors regulating tumorigenic process. Chemokines are cytokines that have chemotactic potential. Chemokine expressed stromal cells. modulate paracrine autocrine They play major modulation cell recruitment, angiogenic potential, proliferation, survival, adhesion, invasion distant sites. addition, new class calcium binding family proteins getting as they significant roles progression modulating TME. Here, highlight recent developments regarding inflammatory chemokine/S100 protein systems We also how chemokines/S100 proteins, TME, ability grow, proliferate, invade metastasize different organs. review highlights possibility using chemokine/chemokine receptor axis promising strategy therapy, current difficulties achieving goal, it could be overcome for successful future therapeutic intervention.