作者: Samir M. Iqbal , Mohammud R. Noor , Swati Goyal , Shawn M. Christensen
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摘要: Devices, systems, and methods for detecting nucleic acid hybridization, including single base mutations at low concentrations, are disclosed, using surface-tethered hairpin loop oligonucleotide probes metal-nanoparticles conjugated to a hybridization detection sequence that is capable of binding the stem region opened probe, without use labeling or target modification recycling.