Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.

摘要: Neural circuits are formed and refined during childhood, including via critical changes in neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic We found that dopamine neurotransmission increases from first to third postnatal week mice precedes reduction spiny projection neuron (SPN) excitability fourth week. In developmentally deficient for dopamine, direct pathway D1-SPNs failed undergo maturation past P18 maintained hyperexcitability into adulthood. absence D1-SPN was due altered phosphatidylinositol 4,5-biphosphate dynamics a consequent lack normal ontogenetic Kir2 currents. Dopamine replacement corrected these deficits SPN when provided birth or specific period juvenile development (P18-P28), but not These results identify sensitive dopamine-dependent maturation, with implications pathophysiology treatment neurodevelopmental disorders.