Crystals and a low resolution structure of interleukin-2.
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DOI: 10.1016/S0021-9258(18)45352-5
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摘要: Abstract Recombinant derived human interleukin-2 and an analog in which cysteine 125 has been replaced with alanine have crystallized a form suitable for x-ray diffraction. The crystals are triclinic, space group P1, two protein molecules the unit cell; cell parameters = 55.8 A, b 40.1 c 33.7 alpha 90.0 degrees, beta 109.3 gamma 93.2 degrees. structure solved to 5.5 A resolution using heavy atom isomorphous replacement methods. resultant low model reveals significant fraction of helical secondary outlines overall tertiary molecule.
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