Targeting the AMP-regulated kinase family to treat diabetes: a research update

摘要: SUMMARY AMP-activated protein kinase (AMPK) has long been recognized as a master energy sensor. Activation of AMPK in response to metabolic stress preserves stores by switching on catabolic pathways, whilst its inhibition consumes the anabolic pathways. Over past 10–15 years, much attention focused role mammalian metabolism, and particularly diabetes. As consequence, emerged more than simple regulator is now involved controlling numerous cellular processes, including cell growth, apoptosis, autophagy polarity. Using different vitro vivo tools, also found play important roles glucose-sensing organs serve key glucose homeostasis mammals. Perhaps most importantly, appears be major target for several antidiabetic drugs. Here, we review recent advances field those emerging from ge...