Solitary cylindroma (dermal analog tumor) of the breast: a previously undescribed neoplasm at this site.

摘要: The authors report a previously undescribed small, well-demarcated breast tumor similar to dermal cylindroma in 63-year-old woman. was an incidental finding lumpectomy specimen for infiltrating lobular carcinoma. surrounded by normal-appearing parenchyma and had the typical "jigsaw" pattern of epithelial basaloid islands. islands showed focal squamous myoepithelial differentiation. A notable number reactive dendritic Langerhans cells permeated cell islands, feature considered be characteristic cylindroma. There also ductal Thick bands hyaline periodic acid-Schiff (PAS) stain collagen IV-positive basement membrane material bordered PAS-collagen globules were seen within no nuclear pleomorphism or mitotic figures. did not express gross cystic disease fluid protein 15, carcinoembryonic antigen, estrogen progesterone receptors, cytokeratin 20 (CK20). diffuse strong immunoreactivity CK AE1/AE3, reactivity CK7 smooth muscle actin. Cylindroma should distinguished from adenoid carcinoma basal Although clearly epithelial, exact histogenesis phenotype this unusual type are unknown.