摘要: When a disease is rare in the general population, genotype relative risks can be estimated from case-control data by adjusting frequencies controls to expected Hardy-Weinberg proportions. The resulting risk estimates are shown have smaller variance than those obtained observed frequencies, and test statistics given for adjusted estimates. tests larger power detecting association, heterogeneity genotypic risks, based on frequencies. An application rheumatoid arthritis HLA-DR antigens.
sci-hub.se 参考文章(7)
Glenys Thomson, A review of theoretical aspects of HLA and disease associations Theoretical Population Biology. ,vol. 20, pp. 168- 208 ,(1981) , 10.1016/0040-5809(81)90009-5
BARNET WOOLF, On estimating the relation between blood group and disease. Annals of Human Genetics. ,vol. 19, pp. 251- 253 ,(1955) , 10.1111/J.1469-1809.1955.TB01348.X
A. SVEJGAARD, L. P. RYDER, HLA genotype distribution and genetic models of insulin‐dependent diabetes mellitus Annals of Human Genetics. ,vol. 45, pp. 293- 298 ,(1981) , 10.1111/J.1469-1809.1981.TB00340.X
A. Svejgaard, C. Jersild, L. STAUB Nielsen, W. F. Bodmer, HL‐A Antigens and Disease Statistical and Genetical Considerations Tissue Antigens. ,vol. 4, pp. 95- 105 ,(2008) , 10.1111/J.1399-0039.1974.TB00230.X
By J. B. S. HALDANE, The estimation and significance of the logarithm of a ratio of frequencies. Annals of Human Genetics. ,vol. 20, pp. 309- 311 ,(1956) , 10.1111/J.1469-1809.1955.TB01285.X
NATHAN MANTEL, JOSEPH L. FLEISS, MINIMUM EXPECTED CELL SIZE REQUIREMENTS FOR THE MANTEL-HAENSZEL ONE-DEGREE-OF-FREEDOM CHI-SQUARE TEST AND A RELATED RAPID PROCEDURE American Journal of Epidemiology. ,vol. 112, pp. 129- 134 ,(1980) , 10.1093/OXFORDJOURNALS.AJE.A112962
John J. Gart, Donald G. Thomas, Numerical Results on Approximate Confidence Limits for the Odds Ratio Journal of the Royal Statistical Society: Series B (Methodological). ,vol. 34, pp. 441- 447 ,(1972) , 10.1111/J.2517-6161.1972.TB00923.X