Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells.

作者: G Bulut , S-H Hong , K Chen , E M Beauchamp , S Rahim

DOI: 10.1038/ONC.2011.245

关键词:

摘要: … (a) GFP-expressing K7M2 OS cells were injected into tail veins of BALB/C mice, and the lungs were dissected. Lung slices were grown in culture media, and tumor growth was …

参考文章(43)
Teemu Mäkitie, Olli Carpén, Tero Kivelä, Antti Vaheri, Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 2442- 2449 ,(2001)
Bruce E Elliott, Jalna A Meens, Sandip K SenGupta, Daniel Louvard, Monique Arpin, The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells Breast Cancer Research. ,vol. 7, pp. 1- 9 ,(2005) , 10.1186/BCR1006
Matthew Fivash, Eric M Towler, Robert J Fisher, BIACORE FOR MACROMOLECULAR INTERACTION Current Opinion in Biotechnology. ,vol. 9, pp. 97- 101 ,(1998) , 10.1016/S0958-1669(98)80091-8
Christopher I. Bayly, Piotr Cieplak, Wendy Cornell, Peter A. Kollman, A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model The Journal of Physical Chemistry. ,vol. 97, pp. 10269- 10280 ,(1993) , 10.1021/J100142A004
Dale L. Boger, Masami Yasuda, Lester A. Mitscher, Steven D. Drake, Paul A. Kitos, Sandra Collins Thompson, Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones. Journal of Medicinal Chemistry. ,vol. 30, pp. 1918- 1928 ,(1987) , 10.1021/JM00393A040
Martin K??bel, Elise Gradhand, Katharina Zeng, Wolfgang D. Schmitt, Karen Kriese, Tilmann Lantzsch, Matthias Wolters, J??rgen Dittmer, Hans G. Strauss, Christoph Thomssen, Steffen Hauptmann, Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma. International Journal of Gynecological Pathology. ,vol. 25, pp. 121- 130 ,(2006) , 10.1097/01.PGP.0000185410.39050.AC
Hye-Rim Park, Woon Won Jung, Patrizia Bacchini, Franco Bertoni, Youn-Wha Kim, Yong-Koo Park, Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. Pathology Research and Practice. ,vol. 202, pp. 509- 515 ,(2006) , 10.1016/J.PRP.2006.01.015
Arnulfo Mendoza, Sung-Hyeok Hong, Tanasa Osborne, Mohammed A. Khan, Kirk Campbell, Joseph Briggs, Ananth Eleswarapu, Lauren Buquo, Ling Ren, Stephen M. Hewitt, El-H. Dakir, Susan Garfield, Renard Walker, Glenn Merlino, Jeffrey E. Green, Kent W. Hunter, Lalage M. Wakefield, Chand Khanna, Modeling metastasis biology and therapy in real time in the mouse lung Journal of Clinical Investigation. ,vol. 120, pp. 2979- 2988 ,(2010) , 10.1172/JCI40252
Anthony Bretscher, Kevin Edwards, Richard G. Fehon, ERM proteins and merlin: integrators at the cell cortex Nature Reviews Molecular Cell Biology. ,vol. 3, pp. 586- 599 ,(2002) , 10.1038/NRM882