Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents.
作者： Min Wang , Mingzhang Gao , Bruce H. Mock , Kathy D. Miller , George W. Sledge
DOI: 10.1016/J.BMC.2006.08.026
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摘要: Fluorinated 2-arylbenzothiazoles are new potential antitumor drugs, which show potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Carbon-11 labeled fluorinated 2-arylbenzothiazoles may serve as novel probes for positron emission tomography (PET) to image tyrosine kinase in cancers. The preparation of 4-fluorinated 2-arylbenzothiazoles 4-fluoro-2-(3-benzloxy-4-methoxyphenyl) benzothiazole (6a) and 4-fluoro-2-(3, 4-dimethoxyphenyl) benzothiazole (6b) was achieved by a modification of …
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