Aromatase CYP19A1, progesterone receptor PGR and estrogen receptor ESR1 gene expression in biopsy specimens of endometrioid heterotopia and endometrial tissue by reverse transcription PCR

摘要: Hypothesis/aims of study. Endometriosis is one the most pressing problems gynecology. Clarifying expression estrogen receptor ( ESR1 ) and progesterone PGR genes polymorphisms in aromatase CYP19A1 gene endometriosis will expand understanding pathogenesis disease causes resistance to its therapy. The objective this study was conduct a comparative analysis mRNA , paired samples eutopic endometrium peritoneal endometrioid lesions order search for predictive markers response hormonal In future, may allow personalizing selection preparations treatment endometriosis. Study design, materials methods. Reverse transcription real-time PCR made it possible evaluate levels studied tissue from 22 patients with 9 women comparison group. Results. Quantitative revealed high heterogeneity level genes, both group, observed only gene. Conclusion. Our findings suggest variability foci This information indicates need an individual approach prescribing targeted therapy, since obvious that effect depend primarily on availability therapeutic target particular patient. absence typical pattern each develop molecular classification common pathology.