Healthy Human T-Cell Responses to Aspergillus fumigatus Antigens
作者： Neelkamal Chaudhary , Janet F. Staab , Kieren A. Marr
DOI: 10.1371/JOURNAL.PONE.0009036
关键词:
摘要: Background Aspergillus fumigatus is associated with both invasive and allergic pulmonary diseases, in different hosts. The organism inhaled as a spore, which, if not cleared from the airway, germinates into hyphal morphotypes that are responsible for tissue invasion resultant inflammation. Hyphae secrete multiple products function antigens, evoking protective (TH1–TH17) destructive (TH2) immunity. How Aspergillus allergens (Asp f proteins) participate development of sensitization unknown.
cabdirect.org
core.ac.uk
harvard.edu
elsevier.com
paperity.org参考文章(46)
Dennis M. Lindell, Thomas A. Moore, Roderick A. McDonald, Galen B. Toews, Gary B. Huffnagle, Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection. Journal of Immunology. ,vol. 174, pp. 7920- 7928 ,(2005) , 10.4049/JIMMUNOL.174.12.7920
Geoffrey M. Gersuk, David M. Underhill, Liqun Zhu, Kieren A. Marr, Dectin-1 and TLRs Permit Macrophages to Distinguish between Different Aspergillus fumigatus Cellular States Journal of Immunology. ,vol. 176, pp. 3717- 3724 ,(2006) , 10.4049/JIMMUNOL.176.6.3717
Priyanka Priyadarsiny, Prabodha K. Swain, P. Usha Sarma, Expression and characterization of Asp fI, an immunodominant allergen/antigen of A. fumigatus in insect cell. Molecular and Cellular Biochemistry. ,vol. 252, pp. 157- 163 ,(2003) , 10.1023/A:1025594620152
Hideaki Kouzaki, Scott M. O'Grady, Christopher B. Lawrence, Hirohito Kita, Proteases Induce Production of Thymic Stromal Lymphopoietin by Airway Epithelial Cells through Protease-Activated Receptor-2 Journal of Immunology. ,vol. 183, pp. 1427- 1434 ,(2009) , 10.4049/JIMMUNOL.0900904
Ralph P Braun, Lendon G Payne, Lichun Dong, Characterization of the IFN-γ T-cell responses to immediate early antigens in humans with genital herpes Virology Journal. ,vol. 3, pp. 54- 54 ,(2006) , 10.1186/1743-422X-3-54
Kiminori Shimizu, Nancy P. Keller, Genetic Involvement of a cAMP-Dependent Protein Kinase in a G Protein Signaling Pathway Regulating Morphological and Chemical Transitions in Aspergillus nidulans Genetics. ,vol. 157, pp. 591- 600 ,(2001) , 10.1093/GENETICS/157.2.591
Reto Crameri, Rolf Jaussi, Günter Menz, Kurt Blaser, Display of Expression Products of cDNA Libraries on Phage Surfaces FEBS Journal. ,vol. 226, pp. 53- 58 ,(1994) , 10.1111/J.1432-1033.1994.00T53.X
Salomé LeibundGut-Landmann, Olaf Groß, Matthew J Robinson, Fabiola Osorio, Emma C Slack, S Vicky Tsoni, Edina Schweighoffer, Victor Tybulewicz, Gordon D Brown, Jürgen Ruland, Caetano Reis e Sousa, None, Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nature Immunology. ,vol. 8, pp. 630- 638 ,(2007) , 10.1038/NI1460
G. Ramadan, B. Davies, V. P. Kurup, C. A. Keever-Taylor, Generation of cytotoxic T cell responses directed to human leucocyte antigen Class I restricted epitopes from the Aspergillus f16 allergen. Clinical and Experimental Immunology. ,vol. 140, pp. 81- 91 ,(2005) , 10.1111/J.1365-2249.2005.02738.X
Banani Banerjee, Viswanath P Kurup, Molecular biology of aspergillus allergens Frontiers in Bioscience. ,vol. 8, pp. s128- 139 ,(2003) , 10.2741/982