The Unexposed Secrets of Prion Protein Oligomers.
作者： Gailing Wang , Mingcheng Wang , Chuanfeng Li
DOI: 10.1007/S12031-015-0546-1
关键词:
摘要: According to the “protein-only” hypothesis, misfolding and conversion of host-derived cellular prion protein (PrPC) into pathogenically misfolded PrP are believed be key procedure in pathogenesis diseases. Intermediate, soluble oligomeric (PrP) aggregates were considered a critical process for Several independent studies on oligomers gained insights oligomers’ formation, biophysical biochemical characteristics, structure conversion, neurotoxicity. rich β-sheet slightly resistant proteinase K digestion. exhibited more neurotoxicity induced neuronal apoptosis vivo and/or vitro. In this review, we summarized recent regarding relationship between death course
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