Design principles for therapeutic angiogenic materials

摘要: Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis — process blood-vessel growth from existing vasculature is regulated by complex interplay biophysical biochemical cues extracellular matrix (ECM), angiogenic factors multiple cell types. The ECM can be regarded as natural 3D material that regulates angiogenesis. Here, we leverage knowledge properties derive design rules for engineering materials. We propose materials should biomimetic, incorporate mimic cooperative interactions between ECM. highlight examples designs demonstrate these principles considerations designing better Angiogenesis mediated cytokines function concert with biofunctional physiological system. By analysing this system, identified biomimetic synthetic systems induce