Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers
作者： S. O. Yesylevskyy , A. P. Demchenko , S. Kraszewski , C. Ramseyer
DOI: 10.1155/2013/965230
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摘要: A remarkable flexibility is observed in biological membranes, which allows them to form the structures of different curvatures. We addressed question intrinsic ability phospholipid membranes highly curved and role cholesterol this process. The distribution asymmetric DOPC/DOPS lipid bilayer was investigated by coarse-grained molecular dynamics simulations membrane patches with large aspect ratio. It shown that induces uneven curvature promoting formation extended flattened regions interleaved sharp bends. affinity anionic DOPS or neutral DOPC lipids dependent. prefers either planar parts membrane. In contrast, narrow interval moderate curvatures preference inverted. Our data suggest there a complex self-consistent interplay between bilayers. suggested new function may have relevance.
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