Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin
作者： Takayuki Hattori , Miho Watanabe-Takahashi , Nobumichi Ohoka , Takashi Hamabata , Koichi Furukawa
DOI: 10.1016/J.FOB.2015.06.005
关键词:
摘要: Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that induced rapid reduction short-lived anti-apoptotic proteins followed by activation caspase 9 and progression apoptosis. Proteasome inhibitors prevented proteins, inhibited suggesting a prerequisite for Stx-induced A clinically approved proteasome inhibitor, bortezomib, prolonged survival mice challenged Stx. These results imply inhibition may be novel approach to prevent effects
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