作者: Mariella Kessler , Irina Schierholz , Martin Mamach , Florian Wilke , Anja Hahne
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摘要: Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority patients showing good outcomes. There is, however, still some unexplained variability in outcomes number cochlear-implant (CI) users, major limitations speech comprehension. The current study used multimodal diagnostic approach combining single-photon emission computed tomography (SPECT) and electroencephalography (EEG) to examine mechanisms underlying processing postlingually deafened CI users (N = 21). In one session, participants performed discrimination task, during which 96-channel EEG was recorded perfusions marker 99mTc-HMPAO injected intravenously. SPECT scan acquired 1.5 h after injection measure cortical activity task. second session included without stimulation at rest. Analysis data showed N400 P600 event-related potentials (ERPs) particularly evoked by semantic violations sentences, enhanced perfusion temporo-frontal network task compared rest, involving auditory cortex bilaterally Broca's area. Moreover, higher performance testing for word recognition verbal intelligence strongly correlated activation this However, comparing lower intelligibility [median split cutoff + 7.6 dB signal-to-noise ratio (SNR) Gottinger sentence test] revealed additional activations parietal occipital regions those stronger superior frontal areas. Furthermore, tightly coupled cognitive abilities, as indicated correlations between (1) amplitudes EEG, (temporal areas)/P600 (parietal areas) (2) left-sided temporal bilateral occipital/parietal areas working memory capacity. These results suggest recruitment close connection ERP effects users. observed differences speech-evoked patterns distinct strategies rehabilitation CI.