HTLV-1, Cytokines,and Cancer

摘要: Human T-cell lymphotropic virus type 1 (HTLV-1), is the causative agent of adult leukemia/lymphoma (ATLL) and a variety immune-mediated disorders (Table 1). Currently, HTLV-1 infection occurs worldwide with endemic regions higher prevalence. Natural transmission these viruses through cell-associated routes that include: orally from breast feeding, sexual contact, by exposure to infected blood or whole cell products. While molecular events replication are beginning be unraveled knowledge about HTLV-1-associated diseases has increased, there remain many questions regarding pathogenesis associated this complex retrovirus. In chapter, we will focus on clinical presentation ATLL emphasis new information viral etiology, pathologic lesions, patient susceptibility factors, host immune responses, and, in particular, role cytokines development ATLL. The epidemiology well known; however, mechanisms used establish persistent subsequently facilitate lymphocyte proliferation while circumventing elimination, less defined.