GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery
作者： Ezequiel Wexselblatt , Jeffrey D. Esko , Yitzhak Tor
DOI: 10.1021/NN507382N
关键词:
摘要: GNeosomes, lysosomotropic lipid vesicles decorated with guanidinoneomycin, can encapsulate and facilitate the cellular internalization lysosomal delivery of cargo ranging from small molecules to high molecular weight proteins, in a process that is exclusively dependent on cell surface glycosaminoglycans. Their uptake mechanism co-localization lysosomes, as well delivery, release, activity internalized cargo, are quantified. GNeosomes proposed universal platform for potential basic research tool therapeutic vehicle.
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