Phosphorylation-specific prolyl isomerization: is there an underlying theme?

摘要: The prolyl isomerase Pin1 is a conserved enzyme that intimately involved in diverse biological processes and pathological conditions such as cancer Alzheimer's disease. By catalysing cis–trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by proline residue (pSer/Thr-Pro), can have profound effects on phosphorylation signalling. structural functional differences result from isomerization specific pSer/Thr-Pro probably underlie most, if not all, Pin1-dependent actions. Phosphorylation-dependent remains unique mode for the modulation signal transduction. Here, we provide an overview plethora regulatory events involve this enzyme, with particular focus oncogenic signalling neurodegeneration.