Preparation of core–shell poly(l-lactic) acid-nanocrystalline apatite hollow microspheres for bone repairing applications

摘要: In this paper, hybrid inorganic–organic core–shell hollow microspheres, made of poly(l-lactic acid) (PLLA) and biomimetic nano apatites (HA), were prepared from biodegradable biocompatible substances, suitable for bone tissue applications. Preparation is started Pickering emulsification, i.e., solid particle-stabilized emulsions in the absence any molecular surfactant, where particles adsorbed to an oil–water interface. Stable oil-in-water produced using 20 nm sized HA nanocrystals as particulate emulsifier a dichloromethane (CH2Cl2) solution PLLA oil phase. Hybrid microspheres at three different surface coverage, ranging 10 50 μm, produced. The resulting materials completely characterized with spectroscopic, calorimetric microscopic techniques cytocompatibility was established by indirect contact tests both fibroblasts osteoblasts direct these latter. They displayed high level thus represent promising drug delivery systems, cell carriers scaffolds regeneration useful treatment orthopaedic, maxillofacial dental fields.