Bone Cell Biology Assessed by Microscopic Approach. Novel insights about bone tissue by new microscopy systems

摘要: The osteocytic cytoplasmic processes show regularly-arranged three-dimensional structure, a cellular network called lacunar-canalicular system (OLCS). We have demonstrated the ultrastructure of OLCS by means structured illumination microscope method (SIM) and Focused Ion Beam-Scanning Electron Microscope (FIB-SEM). also attempted to localize exogenously-administered minodronate, new generation bisphosphonate, as well calcium deposition onto bone forming surface, using an isotope system. Recent devised microscopic technique may provide insights in research field bone.