Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine.
作者： Masao Hirose , Tadashi Ogiso , Ryohei Hasegawa , Masayuki Arai , Nobuyuki Ito
DOI: 10.20772/CANCERSCI1959.71.4_490
关键词:
摘要: The effects of sodium saccharin and caffeine on urinary bladder carcinogenesis in Wistar strain rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were studied. Animals given 0.01% BBN as an initiator for 4 weeks then and/or promoters 32 (Experiment I), or simultaneously 0.001% BBN, 40 II). bladders removed examined by light electron microscopy. Sequential administration after significantly enhanced the induction hyperplasias compared alone simultaneous hyperplasia papillomas Two types developed both experiments. Caffeine had no effect rat epithelium, either sequential caused marked enhancement these
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