Dynamics of nuclear lamina assembly and disassembly.

摘要: What can be concluded about lamin dynamics? a. While the nuclear lamina forms a tight network of proteins, individual members, such as C are only partially bound to lamina. b. A prominent pool nucleoplasmic lamins exists in most cells, which interacts with intranuclear structures (DNA? Histones? Replication and/or transcription complexes?) dynamic fashion. c. During mitosis do not play key role initial reformation envelope. However, they important for correct functioning nucleus immediately after mitosis. Many questions remain unanswered, although have been studied at different levels over 20 years. We just begun understand their crucial several cellular processes. Some that still are: The function foci. Are these native (nuclear channels/tubules) and replication transcription? veil lamins. molecules temporarily result affinity chromosomes or is there functional interaction molecules? extent add membrane organisation. Do keeping intact functional, one many supportive component membrane?