Compelling evidence for a stepwise mechanism of the alkaline cyclisation of uridine 3'-phosphate esters.
作者： Harri Lönnberg , Roger Strömberg , Andrew Williams
DOI: 10.1039/B406926A
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摘要: A Bronsted graph with a convex break at pKa (Lg) = 12.58 provides compelling evidence for an intermediate in the alkaline cyclisation of uridine 3′-phosphate esters. The transient pentacoordinated oxyphosphorane dianion collapses to reactant and cyclic 2′,3′-monophosphate faster than it can pseudo-rotate isomerise 2′-isomer.
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