Palladium-Catalyzed Bis-Functionalization of Isatylidenes: A Facile Route towards Spiro-Indol-2-ones
作者： Sholly Clair George , Jubi John , Saithalavi Anas , Joshni John , Yoshinori Yamamoto
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摘要: An effective protocol has been developed for the construction of 3,3-disubstituted indol-2-ones from isatylidenes by utilizing amphiphilic bis-π-allylpalladium and related intermediates. The strategy is a new method quaternization position 3 indol-2-one towards disubstituted functionalized indol-2-ones. These products were subjected to ring-closing metathesis synthesis spiro[cyclohexene-1,3′-indol]-2′-ones spiro[oxep-5-ene-2,3′-indol]-2′-ones, which are biological interest.
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