Modulation of biological signal transduction by rna interference
作者： Richard Klinghoffer , Stephen Patrick Lewis
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摘要: Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains modulation of biological signal transduction. Shown siRNA that interfere with expression members the protein tyrosine phosphatase (PTP) class enzymes mediate transduction, certain MAP kinase kinases (MKK). In preferred embodiments modulate transduction pathways comprising SHP2, cdc14a/b, cdc25A/B/C, KAP, PTP-e, PRL-3, CD45, dual specificity phosphatase-3 (DSP-3), MKK-4, and/or MKK-7. Modulation PTP-mediated has uses in diseases associated defects cell proliferation, differentiation survival, such metabolic disorders (including diabetes obesity), cancer, autoimmune disease, infectious inflammatory other conditions. The invention also provides chemotherapeutic target polypeptides, DHFR, thymidylate synthetase, topoisomerase I.
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