A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
作者： Per-Ola Freskgård , Thomas Thisted , Torben Ravn Rasmussen , Mikkel Dybro Lundorf
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摘要: In one aspect, the present invention relates to a method for obtaining structural information about an encoded molecule. The molecule may be produced by reaction of plurality chemical entities and capable being connected identifier oligonucleotide containing codons informative identity which have participated in formation certain embodiment, primers are designed complementary appearing on oligonucleotide, presence, absence or relative abundance codon is evaluated mixing primer with presence polymerase substrate (deoxy)ribonucleotide triphosphates measuring extension reaction. another provides selecting compounds binds target. More specifically, target associated initially mixed library complexes, each complex comprising display identifying said Next, due increased proximity, coupled complexes having affinity towards final stage nucleotides analysed deduce at least
google.as 参考文章(78)
Yuri Khmelnitsky, Jonathan S. Dordick, Douglas S. Clark, Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent ,(1994)
Cuneyt Bukusoglu, Method for simultaneous multiple probes/multiple targets screening procedure ,(2002)
Chongjun Xu, Xiao-Hong Qian, Snezana Drmanac, Use of mismatch cleavage to detect complementary probes ,(2001)
Barnett B. Rosenblum, Shaheer H. Khan, Steven M. Menchen, Propargylethoxyamino nucleotide primer extensions ,(2001)
Henrik Pedersen, Multi-step synthesis of templated molecules ,(2003)
Alex Haahr Gouliaev, Henrik Pedersen, Ligational encoding using building block oligonucleotides ,(2005)
Eugeni Namsaraev, Polynucleotide synthesis and labeling by kinetic sampling ligation ,(2003)
Roger S. Cubicciotti, Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices ,(1995)
Daniel W. Norbeck, Anne-Laure Marie Grillot, Jill Edie Hochlowski, Rolf E. Swenson, Thomas J. Sowin, Attached tags for use in combinatorial chemistry synthesis ,(1997)
Bronwyn J. Battersby, Mathias Trau, Christopher R. Miller, Angus Johnston, Jeffrey C. Way, Device and methods for directed synthesis of chemical libraries ,(2002)