A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function

摘要: Aims To assess whether fexofenadine in a range of doses from 80 to 180 mg has any disruptive effects on aspects psychomotor and cognitive function comparison with placebo, loratadine promethazine, an antihistamine known produce impairment. Methods Twenty-four healthy volunteers received 80 mg, 120 mg 180 mg, 10 mg, promethazine 30 mg (as positive internal control) placebo six-way crossover, double-blind study. Following each dose, subjects were required perform series tests performance at 1.5, 3, 6, 9, 12 24 h post dose. The test battery included critical flicker fusion (CFF), choice reaction time (CRT) assessment subjective sedation (LARS). Overall levels activity monitored by means wrist mounted actigraphs throughout the experimental periods. Results Fexofenadine all tested was not statistically different used did cause significant impairment function. Significant impairments found following promethazine. Promethazine caused reduction CFF threshold this effect evident up 12 h dose (P<0.05). There increase recognition 3 6 h administration, drug (P<0.002) percentage ‘sleep-like’ actigraph records during daytime. Conclusions Fexofenadine appears free study where psychometric assessments have been shown be sensitive impairment, as evidenced verum control 30 mg.