Glucose Deprivation Regulates KATP Channel Trafficking via AMP-Activated Protein Kinase in Pancreatic β-Cells

作者: Ajin Lim , Sun-Hyun Park , Jong-Woo Sohn , Ju-Hong Jeon , Jae-Hyung Park

DOI: 10.2337/DB09-0600

关键词:

摘要: OBJECTIVE AMP-activated protein kinase (AMPK) and the ATP-sensitive K + (K ATP ) channel are metabolic sensors that become activated during metabolic stress. AMPK is an …

参考文章(38)
Ian P. SALT, Gabriele JOHNSON, Stephen J. H. ASHCROFT, D. Grahame HARDIE, AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochemical Journal. ,vol. 335, pp. 533- 539 ,(1998) , 10.1042/BJ3350533
S-L Shyng, CG Nichols, Membrane Phospholipid Control of Nucleotide Sensitivity of KATP Channels Science. ,vol. 282, pp. 1138- 1141 ,(1998) , 10.1126/SCIENCE.282.5391.1138
Kenneth R. Hallows, Viswanathan Raghuram, Bruce E. Kemp, Lee A. Witters, J. Kevin Foskett, Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase Journal of Clinical Investigation. ,vol. 105, pp. 1711- 1721 ,(2000) , 10.1172/JCI9622
D.Grahame Hardie, John W Scott, David A Pan, Emma R Hudson, Management of cellular energy by the AMP-activated protein kinase system FEBS Letters. ,vol. 546, pp. 113- 120 ,(2003) , 10.1016/S0014-5793(03)00560-X
E. A. Cartier, L. R. Conti, C. A. Vandenberg, S.-L. Shyng, Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 2882- 2887 ,(2001) , 10.1073/PNAS.051499698
Mhairi C. Towler, D. Grahame Hardie, AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling Circulation Research. ,vol. 100, pp. 328- 341 ,(2007) , 10.1161/01.RES.0000256090.42690.05
Frances M. Ashcroft, Patrik Rorsman, Electrophysiology of the pancreatic beta-cell. Progress in Biophysics & Molecular Biology. ,vol. 54, pp. 87- 143 ,(1989) , 10.1016/0079-6107(89)90013-8
Joost JFP Luiken, Susan LM Coort, Debby PY Koonen, Dick J Van der Horst, Arend Bonen, Antonio Zorzano, Jan FC Glatz, None, Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters. Pflügers Archiv: European Journal of Physiology. ,vol. 448, pp. 1- 15 ,(2004) , 10.1007/S00424-003-1199-4
Kenneth R Hallows, Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism Current Opinion in Nephrology and Hypertension. ,vol. 14, pp. 464- 471 ,(2005) , 10.1097/01.MNH.0000174145.14798.64
Jenna L. Jewell, Wei Luo, Eunjin Oh, Zhanxiang Wang, Debbie C. Thurmond, Filamentous Actin Regulates Insulin Exocytosis through Direct Interaction with Syntaxin 4 Journal of Biological Chemistry. ,vol. 283, pp. 10716- 10726 ,(2008) , 10.1074/JBC.M709876200