摘要: This chapter discusses the perfusion-weighted techniques that can track changes in brain function continuously with both high temporal resolution (seconds) and spatial (millimeters). It provides necessary background for an understanding of functional magnetic resonance imaging (fMRI) mechanisms limitations. The common fMRI methods rely upon protons water as source signal. In principle, this still leaves a large number candidate contrast imaging, including local concentration, transverse longitudinal relaxation rates, phase MRI Changes rates provide basis all forms fMRI. Rapid advances are occurring structural MRI, providing information is complementary, often essential, to Advanced automated or semiautomated algorithms computational neuroanatomy, together tissue classification facilitated by optimize pulse sequences, multiple types contrast, prior information, improving registration, segmentation, morphometry across subjects within subpopulations cross-group comparisons.