Dosis baja de ácido transretinoico en adultos con leucemia promielocítica aguda
作者： Xavier López-Karpovitch , Álvaro Aguayo , Erick Crespo-Solís , Gustavo Ramos-Blas
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摘要: Antecedentes: El tratamiento estandar de la leucemia promielocitica aguda (LPA) incluye acido transretinoico (ATRA) (45 mg/m2) con quimioterapia (QT). Un estudio previo evaluo ATRA a dosis bajas (25 y mostro eficacia clinica parecida estandar. Objetivo: Evaluar remision completa (RC) supervivencia (SV) en adultos LPA novo expuestos baja daunorubicina (DNR). Material metodo: Se incluyeron pacientes diagnosticados entre 2000-2006. consistio fase induccion (IR) + DNR posteriormente tres consolidaciones mg/m2), seguido mantenimiento por 2 anos 6-mercaptopurina, metotrexato mg/m2). Resultados: La mediana edad los 19 fue 31 anos. 78.9% alcanzo RC. mortalidad durante IR 15.8%. Cuarenta ciento enfermos recayeron todos alcanzaron segunda RC QT. Con una seguimiento 2.97 SV 57.9%. Conclusion: logra tasa aceptable. No se recomienda el empleo < 45 mg/m2 alta recaida
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