Urinary peptidomics identifies potential biomarkers for major depressive disorder.

摘要: Major depressive disorder (MDD) is a debilitating psychiatric illness with no available objective laboratory-based diagnostic test. In this study, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based peptidomics was applied to identify potential urinary biomarkers for MDD. A training set of 42 first-episode drug-naive MDD patients and 28 age- gender-matched healthy controls (HC) used develop peptide pattern. Then, the efficacy pattern assessed in an independent blinded test consisting 24 13 HC. combination five identified, yielding sensitivity 91.7% specificity 84.6% set. Moreover, protein precursors four peptides were identified by tandem spectrometric analysis: serum albumin, apolipoprotein A-I, AMBP, basement membrane-specific heparan sulfate proteoglycan core protein. Taken together, may be valuable establishing