Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease.
作者： S.K. Powell , J. Gregory , S. Akbarian , K.J. Brennand
DOI: 10.1016/J.MCN.2017.05.007
关键词:
摘要: CRISPR/Cas9 technology has transformed our ability to manipulate the genome and epigenome, from efficient genomic editing targeted localization of effectors specific loci. Through manipulation DNA- histone-modifying enzyme activities, activation or repression gene expression, targeting transcriptional regulators, role gene-regulatory epigenetic pathways in basic biology disease processes can be directly queried. Here, we discuss emerging CRISPR-based methodologies, with consideration neurobiological applications human induced pluripotent stem cell (hiPSC)-based models.
sci-hub.se 参考文章(145)
Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin, Daniel Wenzel, Louise S. Bicknell, Matthew E. Hurles, Tessa Homfray, Josef M. Penninger, Andrew P. Jackson, Juergen A. Knoblich, Cerebral organoids model human brain development and microcephaly Nature. ,vol. 501, pp. 373- 379 ,(2013) , 10.1038/NATURE12517
Yusuke Miyanari, Céline Ziegler-Birling, Maria-Elena Torres-Padilla, Live visualization of chromatin dynamics with fluorescent TALEs Nature Structural & Molecular Biology. ,vol. 20, pp. 1321- 1324 ,(2013) , 10.1038/NSMB.2680
Toshitsugu Fujita, Hodaka Fujii, Identification of Proteins Associated with an IFNγ-Responsive Promoter by a Retroviral Expression System for enChIP Using CRISPR PLOS ONE. ,vol. 9, pp. 103084- 103084 ,(2014) , 10.1371/JOURNAL.PONE.0103084
Irene Newsham, Yuanqing Wu, Lora Lewis, Yi Han, Benjamin F. Voight, Elaine Lim, Elizabeth Rossin, Andrew Kirby, Jason Flannick, Menachem Fromer, Khalid Shakir, Tim Fennell, Kiran Garimella, Eric Banks, Ryan Poplin, Stacey Gabriel, Mark DePristo, Jack R. Wimbish, Braden E. Boone, Shawn E. Levy, Catalina Betancur, Shamil Sunyaev, Eric Boerwinkle, Joseph D. Buxbaum, Edwin H. Cook Jr, Bernie Devlin, Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe, Mark J. Daly, Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma’ayan, Kaitlin E. Samocha, Aniko Sabo, Chiao-Feng Lin, Christine Stevens, Li-San Wang, Vladimir Makarov, Paz Polak, Seungtai Yoon, Jared Maguire, Emily L. Crawford, Nicholas G. Campbell, Evan T. Geller, Otto Valladares, Chad Schafer, Han Liu, Tuo Zhao, Guiqing Cai, Jayon Lihm, Ruth Dannenfelser, Omar Jabado, Zuleyma Peralta, Uma Nagaswamy, Donna Muzny, Jeffrey G. Reid, Patterns and rates of exonic de novo mutations in autism spectrum disorders Nature. ,vol. 485, pp. 242- 245 ,(2012) , 10.1038/NATURE11011
Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, Sriram Kosuri, Luhan Yang, George M Church, CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology. ,vol. 31, pp. 833- 838 ,(2013) , 10.1038/NBT.2675
Seok-Man Ho, Aaron Topol, Kristen J. Brennand, From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease. Biomarker Insights. ,vol. 2015, pp. 31- 41 ,(2015) , 10.4137/BMI.S20066
Wendy A. Bickmore, Bas van Steensel, Genome architecture: domain organization of interphase chromosomes Cell. ,vol. 152, pp. 1270- 1284 ,(2013) , 10.1016/J.CELL.2013.02.001
Tobias Anton, Sebastian Bultmann, Heinrich Leonhardt, Yolanda Markaki, Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus. ,vol. 5, pp. 163- 172 ,(2014) , 10.4161/NUCL.28488
Paola A. Spadaro, Charlotte R. Flavell, Jocelyn Widagdo, Vikram S. Ratnu, Michael Troup, Chikako Ragan, John S. Mattick, Timothy W. Bredy, Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice Biological Psychiatry. ,vol. 78, pp. 848- 859 ,(2015) , 10.1016/J.BIOPSYCH.2015.02.004
Jeffry D Sander, J Keith Joung, CRISPR-Cas systems for editing, regulating and targeting genomes Nature Biotechnology. ,vol. 32, pp. 347- 355 ,(2014) , 10.1038/NBT.2842