Phenolic composition of orange peels and modulation of redox status and matrix metalloproteinase activities in primary (Caco-2) and metastatic (LoVo and LoVo/ADR) colon cancer cells
作者： Ayokunle O. Ademosun , Ganiyu Oboh , Sabina Passamonti , Federica Tramer , Lovro Ziberna
DOI: 10.1007/S00217-016-2694-0
关键词:
摘要: Orange (Citrus sinensis) peels, consumed in the diet as wines, candies or infusions, are rich sources of phenolic compounds. This study sought to investigate protective ability extracts from orange peels against oxidative stress primary human colonic tumor (Caco-2) and metastatic cell lines (LoVo LoVo/ADR). The effects on glutathione reductase, peroxidase total matrix metalloproteinase (MMP) activities cells were also investigated. results revealed that displayed cellular antioxidant increased reductase cells. Furthermore, inhibited MMP a dose-dependent manner. HPLC fingerprinting presence flavonoids hydroxycinnamic acid. showed exhibited activity colon cancer
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