Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults.

摘要: Objective Research in animals has shown that chronic stress exacerbates tau pathology. In humans, psychological been associated with higher risk of Alzheimer disease clinical syndrome. The objective this cross-sectional study was to assess the hypothesis coping ability (assessed via Brief Resilience Scale [BRS]) is burden and evaluate whether these associations differed by sex amyloid status (A+/A−) cognitively unimpaired (CU) older adults. Methods We included 225 CU participants (mean age 70.4 ± 10.2 years, 48% female) enrolled population-based Mayo Clinic Study Aging who completed BRS underwent amyloid-PET (Pittsburgh compound B–PET) tau-PET (AV1451-PET). fitted multiple regression analysis covariance models between interaction sex. focused on entorhinal cortex (ERC) also performed voxel-wise analyses. Age, sex, education, depression, anxiety were considered as covariates. Results Higher lower medial temporal lobe (including ERC) occipito-temporal cuneal/precuneal cortices. association present both A+ A− but weaker There an restricted such adults abilities showed tau. no significant interactions Conclusions A faster termination response (higher ability) may limit negative effects deposition. Conversely, be early sign accumulating Longitudinal studies are warranted clarify mechanisms act exacerbate pathology or influences stress-related brain lowers cope stress.